histone H3K4me/H3K4me2/H3K4me3 demethylase activity [GO_0034647]

Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.
Tags:

histone H3K4me/H3K4me2/H3K4me3 demethylase activity

ID: GO_0034647

Class

Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.

Comment: Note that the residue position corresponds to the canonical human H3 histone (UniProtKB:P84243); this residue is conserved across all eukaryotes. Residue 1 is the first residue following removal of the initiating Methionine (Met). Note that each histone is encoded by multiple genes, and sequences may vary across different genes within an organism.

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Classification

Alternative Names

Synonym Scope Reference
histone H3-K4me3 demethylase activity related synonym
histone H3-K4me2 demethylase activity broad synonym
histone H3K4me2 demethylase activity broad synonym
histone demethylase activity (H3-trimethyl-K4 specific) exact synonym
histone demethylase activity (H3-K4-me3 specific) exact synonym
histone H3-tri/di/monomethyl-lysine-4 demethylase activity exact synonym
H3K4me3 demethylase activity related synonym